| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| D5401 | 宿迁 | 06:40 | 扬州东 | 07:50 |
| D5404 | 宿迁 | 06:40 | 扬州东 | 07:50 |
| D5405 | 宿迁 | 09:54 | 扬州东 | 11:11 |
| D5408 | 宿迁 | 09:54 | 扬州东 | 11:11 |
| D5409 | 宿迁 | 11:16 | 扬州东 | 12:27 |
| D5412 | 宿迁 | 11:16 | 扬州东 | 12:27 |
| D5413 | 宿迁 | 13:43 | 扬州东 | 15:16 |
| D5416 | 宿迁 | 13:43 | 扬州东 | 15:16 |
| D5515 | 宿迁 | 14:47 | 扬州东 | 16:03 |
| D5471 | 宿迁 | 20:10 | 扬州东 | 21:20 |
| D5474 | 宿迁 | 20:10 | 扬州东 | 21:20 |