| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| C5942 | 贵阳北 | 06:55 | 毕节 | 07:44 |
| C5940 | 贵阳北 | 07:02 | 毕节 | 08:05 |
| C9166 | 贵阳北 | 07:09 | 毕节 | 08:18 |
| D1702 | 贵阳北 | 07:29 | 毕节 | 08:32 |
| C5976 | 贵阳北 | 08:01 | 毕节 | 08:50 |
| D4110 | 贵阳东 | 08:03 | 毕节 | 08:50 |
| C5944 | 贵阳北 | 08:22 | 毕节 | 09:19 |
| C5982 | 贵阳北 | 08:36 | 毕节 | 09:25 |
| C5980 | 贵阳北 | 08:48 | 毕节 | 09:37 |
| C5946 | 贵阳北 | 08:58 | 毕节 | 10:01 |
| C5988 | 贵阳北 | 09:29 | 毕节 | 10:24 |
| C5891 | 贵阳北 | 09:36 | 毕节 | 10:55 |
| G8752 | 贵阳北 | 09:42 | 毕节 | 15:24 |
| G2832 | 贵阳北 | 09:43 | 毕节 | 10:31 |
| D1718 | 贵阳北 | 09:49 | 毕节 | 10:44 |
| G8764 | 贵阳北 | 10:42 | 毕节 | 17:33 |
| C5861 | 贵阳北 | 10:48 | 毕节 | 12:08 |
| G8790 | 贵阳北 | 12:38 | 毕节 | 13:25 |
| C5865 | 贵阳北 | 13:25 | 毕节 | 14:31 |
| D1806 | 贵阳东 | 13:35 | 毕节 | 14:23 |
| D1786 | 贵阳东 | 14:24 | 毕节 | 15:11 |
| C5880 | 贵阳 | 14:58 | 毕节 | 16:19 |
| C5880 | 贵阳北 | 15:19 | 毕节 | 16:19 |
| C5881 | 贵阳北 | 15:26 | 毕节 | 16:53 |
| D1810 | 贵阳东 | 16:01 | 毕节 | 16:48 |
| D1812 | 贵阳东 | 16:08 | 毕节 | 17:13 |
| G2185 | 贵阳东 | 16:22 | 毕节 | 17:07 |
| G2189 | 贵阳东 | 16:46 | 毕节 | 17:31 |
| G3704 | 贵阳东 | 17:07 | 毕节 | 18:11 |
| G2306 | 贵阳东 | 17:27 | 毕节 | 18:24 |
| G2278 | 贵阳东 | 18:07 | 毕节 | 18:58 |
| G2302 | 贵阳东 | 19:09 | 毕节 | 19:54 |
| G8526 | 贵阳 | 19:19 | 毕节 | 20:36 |
| C6692 | 贵阳北 | 19:34 | 毕节 | 20:30 |
| G8526 | 贵阳北 | 19:41 | 毕节 | 20:36 |
| G2193 | 贵阳东 | 19:48 | 毕节 | 20:45 |
| G2971 | 贵阳东 | 20:04 | 毕节 | 20:55 |
| C9180 | 贵阳北 | 20:38 | 毕节 | 21:27 |
| C5948 | 贵阳北 | 20:45 | 毕节 | 21:52 |
| G3706 | 贵阳东 | 20:56 | 毕节 | 21:42 |
| C6362 | 贵阳北 | 21:01 | 毕节 | 21:57 |
| C5950 | 贵阳北 | 21:22 | 毕节 | 22:11 |
| C5698 | 贵阳北 | 21:40 | 毕节 | 22:39 |
| C6668 | 贵阳北 | 21:49 | 毕节 | 22:45 |
| C5686 | 贵阳北 | 22:25 | 毕节 | 23:14 |
| D1862 | 贵阳北 | 22:31 | 毕节 | 23:20 |