| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| G4040 | 贵阳东 | 00:15 | 杭州东 | 06:47 |
| G4041 | 贵阳东 | 00:15 | 杭州东 | 06:47 |
| K80 | 贵阳 | 02:52 | 杭州南 | 02:50 |
| G1332 | 贵阳北 | 06:48 | 杭州东 | 14:36 |
| G1484 | 贵阳北 | 07:45 | 杭州东 | 16:14 |
| K740 | 贵阳 | 07:49 | 杭州南 | 11:31 |
| G1322 | 贵阳北 | 08:51 | 杭州东 | 17:13 |
| G2331 | 贵阳北 | 08:56 | 杭州南 | 17:37 |
| G2334 | 贵阳北 | 08:56 | 杭州南 | 17:37 |
| K112 | 贵阳 | 09:08 | 杭州南 | 10:42 |
| G2194 | 贵阳东 | 09:43 | 杭州南 | 18:07 |
| G2194 | 贵阳东 | 09:43 | 杭州东 | 18:19 |
| G2195 | 贵阳东 | 09:43 | 杭州南 | 18:07 |
| G2195 | 贵阳东 | 09:43 | 杭州东 | 18:19 |
| G1380 | 贵阳北 | 09:56 | 杭州东 | 19:06 |
| G1378 | 贵阳北 | 10:02 | 杭州东 | 18:26 |
| G1334 | 贵阳东 | 10:38 | 杭州东 | 19:53 |
| G1335 | 贵阳东 | 10:38 | 杭州东 | 19:53 |
| G1616 | 贵阳北 | 10:39 | 杭州东 | 18:35 |
| G2336 | 贵阳北 | 10:49 | 杭州东 | 19:19 |
| G1372 | 贵阳北 | 10:54 | 杭州东 | 18:57 |
| G1392 | 贵阳北 | 11:50 | 杭州东 | 20:17 |
| G1328 | 贵阳北 | 11:56 | 杭州东 | 20:24 |
| G1398 | 贵阳北 | 12:19 | 杭州西 | 21:31 |
| G1374 | 贵阳北 | 12:51 | 杭州东 | 21:02 |
| G2190 | 贵阳东 | 13:06 | 杭州东 | 21:19 |
| G2191 | 贵阳东 | 13:06 | 杭州东 | 21:19 |
| G2186 | 贵阳东 | 13:24 | 杭州东 | 22:10 |
| G2187 | 贵阳东 | 13:24 | 杭州东 | 22:10 |
| G1376 | 贵阳北 | 13:31 | 杭州东 | 21:39 |
| G1338 | 贵阳东 | 13:48 | 杭州东 | 22:06 |
| G1339 | 贵阳东 | 13:48 | 杭州东 | 22:06 |
| K496 | 贵阳 | 14:30 | 杭州南 | 13:43 |
| G4832 | 贵阳北 | 14:38 | 杭州东 | 23:09 |
| G1422 | 贵阳北 | 14:50 | 杭州东 | 22:54 |
| G4834 | 贵阳北 | 15:03 | 杭州东 | 23:19 |
| G4836 | 贵阳北 | 15:13 | 杭州东 | 23:24 |
| G4500 | 贵阳北 | 15:35 | 杭州东 | 23:39 |
| K4952 | 贵阳 | 15:36 | 杭州南 | 20:35 |
| K4953 | 贵阳 | 15:36 | 杭州南 | 20:35 |
| G4924 | 贵阳北 | 17:53 | 杭州东 | 01:52 |
| K4602 | 贵阳 | 19:52 | 杭州 | 00:52 |
| K834 | 贵阳 | 20:34 | 杭州南 | 20:48 |
| K835 | 贵阳 | 20:34 | 杭州南 | 20:48 |
| G4944 | 贵阳北 | 22:07 | 杭州东 | 04:40 |
| G4069 | 贵阳东 | 22:36 | 杭州东 | 05:18 |
| G4914 | 贵阳北 | 22:46 | 杭州东 | 05:45 |
| G4049 | 贵阳东 | 23:29 | 杭州东 | 06:42 |