| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| G4538 | 贵阳东 | 05:34 | 毕节 | 06:20 |
| G4308 | 贵阳 | 06:43 | 毕节 | 07:57 |
| G4308 | 贵阳北 | 07:04 | 毕节 | 07:57 |
| G4944 | 贵阳北 | 07:05 | 毕节 | 08:06 |
| G2832 | 贵阳北 | 09:39 | 毕节 | 10:27 |
| G5424 | 贵阳北 | 09:51 | 毕节 | 10:59 |
| G8752 | 贵阳北 | 09:57 | 毕节 | 15:23 |
| G8753 | 贵阳北 | 09:57 | 毕节 | 15:23 |
| G5404 | 贵阳北 | 10:44 | 毕节 | 11:33 |
| G2843 | 贵阳北 | 12:22 | 毕节 | 13:10 |
| G2846 | 贵阳北 | 12:22 | 毕节 | 13:10 |
| G8789 | 贵阳北 | 12:38 | 毕节 | 13:25 |
| G8790 | 贵阳北 | 12:38 | 毕节 | 13:25 |
| G8745 | 贵阳北 | 12:45 | 毕节 | 13:44 |
| G2804 | 贵阳北 | 16:38 | 毕节 | 17:25 |
| G8751 | 贵阳北 | 16:52 | 毕节 | 17:51 |
| G8716 | 贵阳北 | 16:52 | 毕节 | 17:51 |
| G8754 | 贵阳北 | 16:52 | 毕节 | 17:51 |
| G3702 | 贵阳东 | 17:06 | 毕节 | 17:58 |
| G2866 | 贵阳北 | 17:11 | 毕节 | 18:11 |
| G2306 | 贵阳东 | 17:28 | 毕节 | 18:19 |
| G2307 | 贵阳东 | 17:28 | 毕节 | 18:19 |
| G8780 | 贵阳北 | 17:38 | 毕节 | 18:58 |
| G2278 | 贵阳东 | 18:20 | 毕节 | 19:05 |
| G2279 | 贵阳东 | 18:20 | 毕节 | 19:05 |
| G2971 | 贵阳东 | 19:07 | 毕节 | 19:52 |
| G2974 | 贵阳东 | 19:07 | 毕节 | 19:52 |
| G2302 | 贵阳东 | 19:52 | 毕节 | 20:37 |
| G2303 | 贵阳东 | 19:52 | 毕节 | 20:37 |
| G8728 | 贵阳北 | 22:00 | 毕节 | 22:59 |