| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| K9355 | 贵阳 | 06:05 | 毕节 | 10:17 |
| K9358 | 贵阳 | 06:05 | 毕节 | 10:17 |
| C5964 | 贵阳北 | 06:13 | 毕节 | 07:35 |
| C5942 | 贵阳北 | 06:59 | 毕节 | 07:48 |
| D1702 | 贵阳北 | 07:44 | 毕节 | 08:33 |
| C5944 | 贵阳北 | 07:51 | 毕节 | 08:52 |
| C5976 | 贵阳北 | 08:11 | 毕节 | 09:00 |
| D1707 | 贵阳北 | 08:17 | 毕节 | 09:06 |
| C5982 | 贵阳北 | 08:36 | 毕节 | 09:25 |
| C5946 | 贵阳北 | 08:43 | 毕节 | 09:43 |
| C5980 | 贵阳东 | 08:50 | 毕节 | 09:38 |
| G4238 | 贵阳东 | 08:59 | 毕节 | 09:50 |
| G5392 | 贵阳北 | 09:04 | 毕节 | 09:57 |
| C5988 | 贵阳北 | 09:19 | 毕节 | 10:37 |
| G2832 | 贵阳北 | 09:43 | 毕节 | 10:31 |
| D1718 | 贵阳北 | 09:49 | 毕节 | 10:44 |
| G8756 | 贵阳北 | 10:23 | 毕节 | 11:11 |
| G8757 | 贵阳北 | 10:23 | 毕节 | 11:11 |
| G8764 | 贵阳北 | 10:42 | 毕节 | 17:33 |
| G8765 | 贵阳北 | 10:42 | 毕节 | 17:33 |
| C5948 | 贵阳北 | 10:49 | 毕节 | 11:38 |
| C5864 | 贵阳北 | 11:00 | 毕节 | 12:09 |
| C5972 | 贵阳北 | 12:17 | 毕节 | 13:21 |
| G8789 | 贵阳北 | 12:39 | 毕节 | 13:26 |
| G8790 | 贵阳北 | 12:39 | 毕节 | 13:26 |
| K9365 | 贵阳 | 13:57 | 毕节 | 18:42 |
| K9368 | 贵阳 | 13:57 | 毕节 | 18:42 |
| D6166 | 贵阳 | 14:02 | 毕节 | 15:07 |
| D6166 | 贵阳北 | 14:17 | 毕节 | 15:07 |
| D1786 | 贵阳东 | 14:25 | 毕节 | 15:12 |
| C5866 | 贵阳 | 14:58 | 毕节 | 16:19 |
| C5866 | 贵阳北 | 15:19 | 毕节 | 16:19 |
| C5966 | 贵阳北 | 15:30 | 毕节 | 16:32 |
| C5967 | 贵阳北 | 15:30 | 毕节 | 16:32 |
| D1970 | 贵阳东 | 15:40 | 毕节 | 16:27 |
| D1810 | 贵阳东 | 16:00 | 毕节 | 16:47 |
| C5952 | 贵阳北 | 16:03 | 毕节 | 16:52 |
| D1812 | 贵阳东 | 16:10 | 毕节 | 17:14 |
| G2185 | 贵阳东 | 16:24 | 毕节 | 17:09 |
| G2188 | 贵阳东 | 16:24 | 毕节 | 17:09 |
| G2189 | 贵阳东 | 16:46 | 毕节 | 17:31 |
| G2192 | 贵阳东 | 16:46 | 毕节 | 17:31 |
| G2804 | 贵阳北 | 16:49 | 毕节 | 17:37 |
| G3704 | 贵阳东 | 17:07 | 毕节 | 18:11 |
| G2306 | 贵阳东 | 17:27 | 毕节 | 18:24 |
| G2307 | 贵阳东 | 17:27 | 毕节 | 18:24 |
| G2278 | 贵阳东 | 18:07 | 毕节 | 18:58 |
| G2279 | 贵阳东 | 18:07 | 毕节 | 18:58 |
| C5990 | 贵阳北 | 18:22 | 毕节 | 19:17 |
| G2302 | 贵阳东 | 19:09 | 毕节 | 19:54 |
| G2303 | 贵阳东 | 19:09 | 毕节 | 19:54 |
| G8526 | 贵阳 | 19:19 | 毕节 | 20:35 |
| C5960 | 贵阳北 | 19:22 | 毕节 | 20:22 |
| G8526 | 贵阳北 | 19:41 | 毕节 | 20:35 |
| G2193 | 贵阳东 | 19:48 | 毕节 | 20:45 |
| G2196 | 贵阳东 | 19:48 | 毕节 | 20:45 |
| D6168 | 贵阳 | 19:51 | 毕节 | 21:21 |
| G2971 | 贵阳东 | 20:04 | 毕节 | 20:55 |
| G2974 | 贵阳东 | 20:04 | 毕节 | 20:55 |
| D6168 | 贵阳北 | 20:20 | 毕节 | 21:21 |
| G3706 | 贵阳东 | 20:56 | 毕节 | 21:42 |
| G4992 | 贵阳东 | 20:56 | 毕节 | 21:42 |
| C5962 | 贵阳北 | 22:10 | 毕节 | 22:59 |
| D1862 | 贵阳北 | 22:42 | 毕节 | 23:31 |
| C5978 | 贵阳北 | 22:50 | 毕节 | 23:39 |