| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| K9355 | 贵阳 | 06:00 | 毕节 | 10:21 |
| K9358 | 贵阳 | 06:00 | 毕节 | 10:21 |
| D4974 | 贵阳东 | 06:10 | 毕节 | 06:57 |
| C5942 | 贵阳北 | 06:55 | 毕节 | 07:50 |
| C5940 | 贵阳北 | 07:16 | 毕节 | 08:19 |
| D1702 | 贵阳北 | 07:29 | 毕节 | 08:32 |
| C5830 | 贵阳北 | 07:45 | 毕节 | 08:42 |
| D4330 | 贵阳东 | 07:54 | 毕节 | 09:19 |
| C5976 | 贵阳北 | 07:59 | 毕节 | 08:48 |
| D1707 | 贵阳北 | 08:13 | 毕节 | 09:02 |
| C5944 | 贵阳北 | 08:29 | 毕节 | 09:26 |
| C5980 | 贵阳北 | 08:41 | 毕节 | 09:30 |
| D4018 | 贵阳东 | 08:48 | 毕节 | 09:35 |
| C5946 | 贵阳北 | 08:53 | 毕节 | 10:02 |
| G4238 | 贵阳东 | 09:11 | 毕节 | 10:08 |
| D4892 | 贵阳东 | 09:25 | 毕节 | 10:19 |
| G2832 | 贵阳北 | 09:39 | 毕节 | 10:27 |
| G8752 | 贵阳北 | 09:42 | 毕节 | 15:24 |
| G8753 | 贵阳北 | 09:42 | 毕节 | 15:24 |
| D1718 | 贵阳北 | 09:51 | 毕节 | 10:40 |
| C5891 | 贵阳北 | 09:58 | 毕节 | 11:15 |
| G8764 | 贵阳北 | 10:42 | 毕节 | 17:33 |
| G8765 | 贵阳北 | 10:42 | 毕节 | 17:33 |
| C5861 | 贵阳北 | 10:54 | 毕节 | 12:03 |
| C5864 | 贵阳北 | 10:54 | 毕节 | 12:03 |
| D4250 | 贵阳东 | 11:06 | 毕节 | 12:13 |
| C5871 | 贵阳北 | 11:30 | 毕节 | 12:45 |
| C5874 | 贵阳北 | 11:30 | 毕节 | 12:45 |
| G8789 | 贵阳北 | 12:38 | 毕节 | 13:25 |
| G8790 | 贵阳北 | 12:38 | 毕节 | 13:25 |
| G8745 | 贵阳北 | 12:45 | 毕节 | 13:44 |
| G2165 | 贵阳东 | 13:15 | 毕节 | 14:00 |
| G2168 | 贵阳东 | 13:15 | 毕节 | 14:00 |
| G4067 | 贵阳东 | 13:27 | 毕节 | 14:34 |
| D1806 | 贵阳东 | 13:35 | 毕节 | 14:24 |
| C5826 | 贵阳北 | 13:46 | 毕节 | 15:09 |
| C5865 | 贵阳北 | 14:35 | 毕节 | 15:31 |
| K9365 | 贵阳 | 14:35 | 毕节 | 19:31 |
| K9368 | 贵阳 | 14:35 | 毕节 | 19:31 |
| C5880 | 贵阳 | 14:55 | 毕节 | 16:17 |
| C5880 | 贵阳北 | 15:19 | 毕节 | 16:17 |
| C5881 | 贵阳北 | 15:26 | 毕节 | 16:53 |
| C5834 | 贵阳北 | 15:39 | 毕节 | 17:13 |
| D1810 | 贵阳东 | 16:01 | 毕节 | 16:48 |
| C5875 | 贵阳北 | 16:18 | 毕节 | 17:19 |
| G2185 | 贵阳东 | 16:20 | 毕节 | 17:05 |
| G2188 | 贵阳东 | 16:20 | 毕节 | 17:05 |
| G2189 | 贵阳东 | 16:45 | 毕节 | 17:31 |
| G2192 | 贵阳东 | 16:45 | 毕节 | 17:31 |
| G8751 | 贵阳北 | 16:55 | 毕节 | 17:49 |
| G8754 | 贵阳北 | 16:55 | 毕节 | 17:49 |
| G3704 | 贵阳东 | 17:03 | 毕节 | 18:01 |
| G2866 | 贵阳北 | 17:06 | 毕节 | 18:12 |
| G2306 | 贵阳东 | 17:27 | 毕节 | 18:18 |
| G2307 | 贵阳东 | 17:27 | 毕节 | 18:18 |
| C5885 | 贵阳北 | 17:30 | 毕节 | 18:42 |
| C5888 | 贵阳北 | 17:30 | 毕节 | 18:42 |
| G2278 | 贵阳东 | 18:07 | 毕节 | 18:58 |
| G2279 | 贵阳东 | 18:07 | 毕节 | 18:58 |
| G2302 | 贵阳东 | 19:07 | 毕节 | 19:52 |
| G2303 | 贵阳东 | 19:07 | 毕节 | 19:52 |
| G2971 | 贵阳东 | 19:24 | 毕节 | 20:27 |
| G2974 | 贵阳东 | 19:24 | 毕节 | 20:27 |
| G4900 | 贵阳东 | 19:40 | 毕节 | 20:33 |
| G2193 | 贵阳东 | 19:47 | 毕节 | 20:44 |
| G2196 | 贵阳东 | 19:47 | 毕节 | 20:44 |
| C9180 | 贵阳北 | 19:53 | 毕节 | 20:50 |
| C5950 | 贵阳北 | 20:24 | 毕节 | 21:27 |
| C5948 | 贵阳北 | 20:41 | 毕节 | 21:37 |
| C9176 | 贵阳北 | 20:49 | 毕节 | 21:48 |
| G4932 | 贵阳东 | 21:08 | 毕节 | 21:53 |
| D1862 | 贵阳 | 21:56 | 毕节 | 23:21 |
| D1862 | 贵阳北 | 22:32 | 毕节 | 23:21 |
| C9186 | 贵阳北 | 23:03 | 毕节 | 23:52 |