| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| G4538 | 贵阳东 | 05:26 | 毕节 | 06:12 |
| K9355 | 贵阳 | 06:00 | 毕节 | 10:16 |
| K9358 | 贵阳 | 06:00 | 毕节 | 10:16 |
| C5942 | 贵阳北 | 06:50 | 毕节 | 07:39 |
| C5940 | 贵阳北 | 07:17 | 毕节 | 08:20 |
| D1707 | 贵阳 | 08:10 | 毕节 | 09:14 |
| D1707 | 贵阳北 | 08:25 | 毕节 | 09:14 |
| C5944 | 贵阳北 | 08:33 | 毕节 | 09:30 |
| G8778 | 贵阳北 | 09:00 | 毕节 | 09:47 |
| G2832 | 贵阳北 | 09:39 | 毕节 | 10:27 |
| D1718 | 贵阳北 | 09:51 | 毕节 | 10:40 |
| G8752 | 贵阳北 | 09:56 | 毕节 | 15:23 |
| G8753 | 贵阳北 | 09:56 | 毕节 | 15:23 |
| C5891 | 贵阳北 | 09:58 | 毕节 | 11:28 |
| C5861 | 贵阳北 | 10:54 | 毕节 | 12:08 |
| C5864 | 贵阳北 | 10:54 | 毕节 | 12:08 |
| D4284 | 贵阳 | 11:07 | 毕节 | 12:18 |
| D4284 | 贵阳北 | 11:22 | 毕节 | 12:18 |
| C5871 | 贵阳北 | 11:30 | 毕节 | 12:45 |
| C5874 | 贵阳北 | 11:30 | 毕节 | 12:45 |
| D8556 | 贵阳东 | 12:11 | 毕节 | 12:58 |
| D8560 | 贵阳东 | 12:11 | 毕节 | 12:58 |
| C6382 | 贵阳北 | 12:15 | 毕节 | 13:04 |
| G2843 | 贵阳北 | 12:22 | 毕节 | 13:10 |
| G2846 | 贵阳北 | 12:22 | 毕节 | 13:10 |
| G8789 | 贵阳北 | 12:38 | 毕节 | 13:25 |
| G8790 | 贵阳北 | 12:38 | 毕节 | 13:25 |
| G8745 | 贵阳北 | 12:45 | 毕节 | 13:44 |
| C9168 | 贵阳 | 12:58 | 毕节 | 14:20 |
| C9168 | 贵阳北 | 13:17 | 毕节 | 14:20 |
| C5838 | 贵阳 | 14:19 | 毕节 | 15:29 |
| C5838 | 贵阳北 | 14:32 | 毕节 | 15:29 |
| K9365 | 贵阳 | 14:33 | 毕节 | 19:27 |
| K9368 | 贵阳 | 14:33 | 毕节 | 19:27 |
| C5880 | 贵阳 | 14:58 | 毕节 | 16:22 |
| C5880 | 贵阳北 | 15:14 | 毕节 | 16:22 |
| C5881 | 贵阳北 | 15:25 | 毕节 | 16:27 |
| C5875 | 贵阳北 | 16:18 | 毕节 | 17:16 |
| G2804 | 贵阳北 | 16:38 | 毕节 | 17:25 |
| G8751 | 贵阳北 | 16:52 | 毕节 | 17:51 |
| G8754 | 贵阳北 | 16:52 | 毕节 | 17:51 |
| G3702 | 贵阳东 | 17:06 | 毕节 | 17:58 |
| G2866 | 贵阳北 | 17:11 | 毕节 | 18:11 |
| G2306 | 贵阳东 | 17:28 | 毕节 | 18:19 |
| G2307 | 贵阳东 | 17:28 | 毕节 | 18:19 |
| G9584 | 贵阳 | 18:07 | 毕节 | 19:17 |
| G2278 | 贵阳东 | 18:20 | 毕节 | 19:05 |
| G2279 | 贵阳东 | 18:20 | 毕节 | 19:05 |
| C9176 | 贵阳北 | 18:22 | 毕节 | 19:23 |
| G9584 | 贵阳北 | 18:23 | 毕节 | 19:17 |
| D1728 | 贵阳 | 18:56 | 毕节 | 20:01 |
| G2971 | 贵阳东 | 19:07 | 毕节 | 19:52 |
| G2974 | 贵阳东 | 19:07 | 毕节 | 19:52 |
| D1728 | 贵阳北 | 19:12 | 毕节 | 20:01 |
| C5948 | 贵阳北 | 19:35 | 毕节 | 20:31 |
| G8768 | 贵阳北 | 19:44 | 毕节 | 20:56 |
| G2302 | 贵阳东 | 19:52 | 毕节 | 20:43 |
| G2303 | 贵阳东 | 19:52 | 毕节 | 20:43 |
| C9170 | 贵阳 | 19:54 | 毕节 | 21:05 |
| C9180 | 贵阳北 | 19:56 | 毕节 | 20:51 |
| C9170 | 贵阳北 | 20:09 | 毕节 | 21:05 |
| C5950 | 贵阳北 | 20:23 | 毕节 | 21:24 |
| C9172 | 贵阳北 | 20:39 | 毕节 | 21:40 |
| C5584 | 贵阳北 | 20:51 | 毕节 | 22:10 |
| C9166 | 贵阳北 | 21:50 | 毕节 | 22:52 |
| D1862 | 贵阳 | 21:57 | 毕节 | 23:19 |
| D1862 | 贵阳北 | 22:30 | 毕节 | 23:19 |